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Folic acid supplement decreases the homocysteine increasing effect of filtered coffee. A randomised placebo-controlled study

Objective: Elevated levels of plasma total homocysteine (tHcy) are identified as independent risk factors for coronary heart disease and for fetal neural tube defects. tHcy levels are negatively associated with folic acid, pyridoxine and cobalamine, and positively associated with coffee consumption and smoking. A total of 600 ml of filtered coffee results in a tHcy increase that 200 μg of folic acid or 40 mg of pyridoxine supplementation might eliminate. Design: Randomised, blinded study with two consecutive trial periods. Setting: Free living population. Volunteers. Subjects: A total of 121 healthy, nonsmoking men and women (78%) aged 29–65 y. Interventions: (1) A coffee-free period of 3 weeks, (2) 600 ml coffee/day and a supplement of 200 μg folic acid/day or placebo for 4 weeks, (3) 3-week coffee-free period, (4) 600 ml coffee/day and 40 mg pyridoxine/day or placebo for 4 weeks. Main outcome measures: The difference between the change in tHcy in the supplement group and the change in tHcy in the placebo group during the 4-week trial period. Results: Coffee abstention resulted in a tHcy decrease of 1.04 μmol/l for the whole group. In the subsequent coffee period, a further decrease of 0.17 μmol/l was observed in the folic acid group whereas an increase of 1.26 μmol/l was observed in the placebo group, the difference was 1.43 μmol/l (95% CI: 0.80, 2.07). Pyridoxine supplement had no impact on tHcy levels. Conclusions: Supplementation of 200 μg folic acid/day eliminates the tHcy increasing effect of 600 ml filtered coffee in subjects not already on folic acid supplements. A supplement of 40 mg pyridoxine/day does not have the same effect. Sponsorship: None.

What’s the best vitamin C supplement?

Cold and flu season is upon us and stocking up on a good vitamin C supplement is one way that’s believed to keep sickness at bay. Vitamin C is best known for boosting the immune system, but it’s also a powerful antioxidant with many other benefits, including fighting inflammation. Your body doesn’t produce vitamin C […]

The best vitamin C supplement of 2020

A powerful antioxidant and a vital contributor to cell and immune health, it’s important to take a vitamin C supplement if you don’t think you get enough in your diet. Unless you take extremely high doses, there’s no harm in consuming slightly more vitamin C than you need, so many people take a better-safe-than-sorry approach. […]

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7 Dietitian-Approved B Complex Vitamins to Meet Your Needs

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What's Glucosamine Good For and Who Should Steer Clear?

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Several states have banned kratom, an unregulated supplement, that has been linked to six deaths in Los Angeles County

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Meticore Reviews – Legit Weight Loss Pills or Scam Consumer Complaints? [2021 Review]

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